PUBLICATIONS

Complete list of published work on My Bibliography and Google Scholar.
#: Corresponding author.

At UAB

1. Bhat P, Van Amburg JC, Potts CR, Gracie TJ, Cartailler JA, Parker AC, Savona MR, Lu R, Lee SC, Welner RS, Bick AG, Ferrell PB. A 30-gene classifier distinguishes low-risk MDS HSPCs from healthy HSPCs. Exp Hematol. 2025 Dec;152:105252.

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2. Zhou X*, Moreira S*, Restelli C, Wang H, Jahangiri S, Aryal S, Tsao E, Zhang P, Niu M, Kumar H, Balde Z, Vujovic A, Liu L, Wong N, Arruda A, Minden MD, Zhou Y, Ravi B, Qi J, Li C, Hope KJ#, Lu R#. Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models. Sci Transl Med. 2025 Aug 6;17(810):eadn5400. (* equal contribution)

   ┃ PDF ┃GEO: RNA-seq & Cut&Run┃

3. Wang M, Li H, Han C, Chen Y, He L, Xie M, Lal H, Fast VG, Moellering DR, Zhang J, Lu R, Young M, Zhou Y. Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan. Am J Physiol Heart Circ Physiol. 2025 Aug 1;329(2):H315-H329.

   ┃ PDF ┃GEO┃

4. Goel P, Aryal S, Franceski AM, Kuznetsova V, Costa A, Luca F, Connelly AN, Phillips DW, Ennis CC, Curtiss BM, Karfa S, Crown BL, Larson CR, Carminita E, Camacho V, Welsch D, Cheng C, Yokota A, Cobo I, Hirai H, Lu R, Bhatia R, Datta PK, Ferrell PB, Welner RS. The acute myeloid leukemia microenvironment impairs neutrophil maturation and function through NF-κB signaling. Blood. 2025 Oct 2;146(14):1707-1721.

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5. Prieto-Dominguez N, Goel P, Ojo OA, Moretto K, Holtzhausen A, Humphryes A, Zhou X, Kuznetsova V, Dempsey F, Pittman K, Lu R, Green TJ, Shi LZ, Welner RS, Earp HS, Ubil E. PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy. Cancer Immunol Res. 2025 May 2;13(5):749-766.

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6. Jenkins MT, Chu YE, Franceski AM, Potts CR, Dubin R, Dickerson KM, Lee SC, Lu R, Welner RS, Ferrell PB. TET2-loss enhances immediate and time-resolved interferon-γ signaling responses across myeloid differentiation. Exp Hematol. 2025 Apr;144:104727.

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7. Zhang L, Zhou X, Aryal S, Veasey V, Zhang P, Li FJ, Luan Y, Bhatia R, Zhou Y, Lu R#. CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator. Cell Death Dis. 2024 Aug 27;15(8):627.
   - Highlighted in CRISPR Medicine News

   ┃ PDF ┃GEO: RNA-seq┃GEO: Cut&Run┃

8. Zhou X*, Zhang L*, Aryal S, Veasey V, Tajik A, Restelli C, Moreira S, Zhang P, Zhang Y, Hope K, Zhou Y, Cheng C, Bhatia R, Lu R#. Epigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia. Blood. Nov 7;144(19):2018-2032. (* equal contribution)
   - Cover story of Blood
   - Commentary in Blood: Azimi N, Deshpande AJ. Broken brakes: PRC loss foils menin inhibition. Blood. 2024 Nov 7;144(19):1979-1980.

   ┃ PDF ┃GEO: RNA-seq┃GEO: ChIP-seq┃

9. Paul T, Zhang P, Zhang Z, Fargason T, De Silva NIU, Powell E, Ekpenyong E, Jamal S, Yu Y, Prevelige P, Lu R, Zhang J. The U1-70K and SRSF1 interaction is modulated by phosphorylation during the early stages of spliceosome assembly. Protein Sci. 2024 Aug;33(8):e5117.

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10. Lu YA, Sun J, Wang L, Wang M, Wu Y, Getachew A, Matthews RC, Li H, Peng WG, Zhang J, Lu R, Zhou Y. ELM2-SANT Domain-Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells. J Am Heart Assoc. 2024 Jul 2;13(13):e034816.

    ┃ PDF ┃GEO┃

11. Qiu S, Sheth VS, Yan C, Liu J, Chacko BK, Li H, Crossman DK, Fortmann SD, Aryal S, Rennhack A, Grant MB, Welner RS, Paterson AJ, Wende AR, Darley-Usmar VM, Lu R, Locasale JW, Bhatia R. Metabolic Adaptation to Tyrosine Kinase Inhibition in Leukemia Stem Cells. Blood. 2023 Aug 10;142(6):574-588.

    ┃ PDF ┃GEO┃

12. Wright S, Hu J, Wang H, Hyle J, Zhang Y, Du G, Konopleva MY, Kornblau SM, Djekidel MN, Rosikiewicz W, Xu B, Lu R, Yang JJ, Li C. Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2220134120.

    ┃ PDF ┃GEO┃

13. Zhou X, Zhang P, Aryal S, Zhang L, Lu R#. UTX Loss Alters Therapeutic Responses in KMT2A-rearranged Acute Myeloid Leukemia. Leukemia.2023 Jan;37(1):226-230.

    ┃ PDF ┃GEO: RNA-seq & ChIP-seq┃

14. Qiu S, Kumar H, Yan C, Li H, Paterson AJ, Anderson NR, He J, Yang J, Xie M, Crossman DK, Lu R, Welner RS, Bhatia R. Autophagy inhibition impairs leukemia stem cell function in FLT3-ITD AML but has antagonistic interactions with tyrosine kinase inhibition. Leukemia. 2022 Nov;36(11):2621-2633.

    ┃ PDF ┃GEO┃

15. Zhou X, Lu R#. HOXA9/MEIS1 targets in leukemia: reinforced signaling networks and therapeutic opportunities. Haematologica. 2023 May 1;108(5):1205-1207.

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16. Aryal S*, Zhang Y*, Wren S, Li C#, Lu R#. Molecular Regulators of HOXA9 in Acute Myeloid Leukemia. FEBS J. 2023 Jan;290(2):321-339. (*equal contribution)

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17. Tang Y*, Aryal S*, Geng X, Zhou X, Fast VG, Zhang J, Lu R#, Zhou Y#. TBX20 Improves Contractility and Mitochondrial Function during Direct Human Cardiac Reprogramming. Circulation. 2022 Nov 15;146(20):1518-1536. (* equal contribution)

    ┃ PDF ┃GEO: ATAC-seq, CUT&Run, CUT&Tag, RNA-seq & scRNA-seq┃

18. Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S. Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity. Nat Commun. 2022 Apr 29;13(1):2350.

    ┃ PDF ┃ GEO ┃

19. Zhao L, Zhang P, Galbo PM, Zhou X, Aryal S, Qiu S, Zhang H, Zhou Y, Li C, Zheng D, Bhatia R, Lu R#. Transcription Factor MEF2D is Required for the Maintenance of MLL-rearranged Acute Myeloid Leukemia. Blood Adv. 2021 Nov 23;5(22):4727-4740.

    ┃ PDF ┃ GEO: ATAC-seq ┃GEO: RNA-seq┃GEO: ChIP-seq┃

20. Xu B, Wang H, Wright S, Hyle J, Zhang Y, Shao Y, Niu M, Fan Y, Rosikiewicz W, Djekidel MN, Peng J, Lu R, Li C. Acute depletion of CTCF rewires genome-wide chromatin accessibility. Genome Biol. 2021 Aug 24;22(1):244.

    ┃ PDF ┃ GEO: ATAC-seq & WGBS ┃

21. Patel SB, Nemkov T, Stefanoni D, Benavides GA, Bassal MA, Crown BL, Matkins VR, Camacho V, Kuznetsova V, Hoang AT, Tenen DE, Wolock SL, Park J, Ying L, Yue Z, Chen JY, Yang H, Tenen DG, Ferrell PB, Lu R, Darley-Usmar V, D'Alessandro A, Bhatia R, Welner RS. Metabolic alterations mediated by STAT3 promotes drug persistence in CML. Leukemia. 2021 Dec;35(12):3371-3382.

    ┃ PDF ┃ GEO: RNA-seq & ChIP-seq ┃

22. Tang Y, Zhao L, Yu X, Zhang J, Qian L, Jin J, Lu R, Zhou Y. Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogramming. Stem Cell Research. 2021, May;53:102365.

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23. Zhang H*, Zhang Y*, Zhou X*, Wright S, Hyle J, Zhao L, An J, Zhao X, Shao Y, Xu B, Lee HM, Chen T, Zhou Y, Chen X, Lu R#, Li C#. Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen. Elife. 2020, Oct 1;9:e57858. (*equal contribution)

    ┃ PDF ┃ GEO: CUNRUN ┃

24. Pi WC, Wang J, Shimada M, Lin JW, Geng H, Lee YL, Lu R, Li D, Wang GG, Roeder RG, Chen WY. E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia. Blood. 2020 Jul 2;136(1):11-23.

    ┃ PDF ┃ GEO: RNA-seq & ChIP-seq ┃

25. Lu R, J Wang, Z Ren, J Yin, Y Wang, L Cai, GG Wang. A model system for studying the DNMT3A hotspot mutation (DNMT3AR882) demonstrates a causal relationship between its dominant-negative effect and leukemogenesis. Cancer Research 2019, 79(14): 3583-3594.

    ┃ PDF ┃GEO: HumanMethylation450 BeadChip ┃ GEO: Microarray ┃

    
    

    Before UAB

26. Cai L, Tsai YH, Wang P, Wang J, Li D, Fan H, Zhao Y, Bareja R, Lu R, Wilson EM, Sboner A, Whang YE, Zheng D, Parker JS, Earp HS, Wang GG. ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. Molecular Cell 2018, 72(2):341-354.

    ┃ PDF ┃ GEO: RNA-seq & ChIP-seq ┃

27. Xu B, Cai L, Butler JM, Chen D, Lu X, Allison DF, Lu R, Rafii S, Parker JS, Zheng D, Wang GG. The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports 2018, 10(3):675-683.

    ┃ PDF ┃ GEO: RNA-seq ┃GEO: ATAC-seq ┃GEO: ChIP-seq ┃

28. Zhang ZM*, Lu R*, Wang P, Yu Y, Liu S, Ji D, Gao L, Rothbart SB, Wang Y, Wang GG, Song J. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature 2018, 554(7692):387-391. (*equal contribution)

    ┃ PDF ┃ GEO: eRRBS ┃ GEO: HumanMethylation450 BeadChip ┃

    • Highlighted in Cancer Discovery.

29. Lu R, Wang GG. Pharmacologic Targeting of Chromatin Modulators as Therapeutics of Acute Myeloid Leukemia. Frontiers in Oncology 2017 Oct 12;7:241.

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30. Lu R, Wang GG. Gene enhancer deregulation and epigenetic vulnerability. Oncoscience 2016, 3(11-12):299-301.

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31. Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen W-Y, Abdel-Wahab O, Wade PA, Zheng D, Wang GG. Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development. Cancer Cell 2016, 30(1):92-107.

    ┃ PDF ┃ GEO: eRRBS, ChIP-seq, and Microarray ┃

    • Cover story of Cancer Cell

    • Highlighted in Cancer Cell and Cancer Discovery.

32. Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin C, Fu J-D, Wang GG, Liu J, Qian L. Bmi1 is a key epigenetic barrier to direct cardiac reprogramming. Cell Stem Cell 2016, 18(3):382-395.

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33. Yu H, He K, Wang L, Hu J, Gu J, Zhou C, Lu R, Jin Y. Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins. Journal of Cell Science 2015, 128(15):2881-2890.

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34. Lu R, Wang GG. Tudor: a versatile family of histone methylation ‘readers’. Trends in Biochemical Sciences 2013, 38(11):546-555.

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35. Cai L*, Rothbart SB*, Lu R*, Xu B, Chen W-Y, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J, Wang GG. An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell 2013, 49(3):571-582. (*equal contribution)

    ┃ PDF ┃ GEO: Microarray ┃

36. Yang A, Shi G, Zhou C, Lu R, Li H, Sun L, Jin Y. Nucleolin maintains embryonic stem cell self-renewal by suppression of p53 protein-dependent pathway. Journal of Biological Chemistry 2011, 286(50):43370-43382.

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37. Lu R, Yang A, Jin Y. Dual functions of T-box 3 (Tbx3) in the control of self-renewal and extraembryonic endoderm differentiation in mouse embryonic stem cells. Journal of Biological Chemistry 2011, 286(10):8425-8436.

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38. Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Kwon SW, Zhao Y, Li J, Jin Y. Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Proceedings of the National Academy of Sciences 2010, 107(4):1402-1407.

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39. Li H, Wang B, Yang A, Lu R, Wang W, Zhou Y, Shi G, Kwon SW, Zhao Y, Jin Y. Ly-1 Antibody Reactive Clone Is an Important Nucleolar Protein for Control of Self-renewal and Differentiation in Embryonic Stem Cells. Stem Cells 2009, 27(6):1244-1254.

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40. Wang BB, Lu R, Wang WC, Jin Y. Inducible and reversible suppression of Npm1 gene expression using stably integrated small interfering RNA vector in mouse embryonic stem cells. Biochemical and Biophysical Research Communications 2006, 347(4):1129-1137.

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    Book Chapters

41. Aryal S, Lu R#. HOXA9 Regulome and Pharmacological Interventions in Leukemia. Adv Exp Med Biol. 2024;1459:405-430.

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42. Zhang P, Lu R#. The Molecular and Biological Function of MEF2D in Leukemia. Adv Exp Med Biol. 2024;1459:379-403.

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